Abstract: Melanoma antigen A is a kind of tumor-associated antigen, which expresses in various types of hunman malignant tumor tissues especially in melanoma. Hepatocellular carcinoma (HCC) is a kind of malignant epithelialtumor with high incidence which occurs in liver. Searching for effective diagnosis and treatment methods of it become a pressing task. It is confirmed that MAGE-A gene is highly expressed in HCC tissues which has great significance to the diagnosis, treatment and prognosis for HCC.