Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (2): 106-110.doi: 10.3760/cma.j.cn371439-20210607-00017

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Clinical significance of expression of tumor immunogenic cell death related molecules

Xu Lu1, Long Jinhua2, Jin Feng2(), Wu Weili2   

  1. 1School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, China
    2Department of Head and Neck Oncology, Cancer Hospital Affiliated to Guizhou Medical University, Guiyang 550000, China
  • Received:2021-06-07 Revised:2021-12-15 Online:2022-02-08 Published:2022-03-11
  • Contact: Jin Feng E-mail:jinf8865@yeah.net
  • Supported by:
    National Natural Science Foundation of China(82060555);Guizhou Science and Technology Planning Project (〔2019〕1266);Guizhou Science and Technology Basic Research Program (〔2017〕1148)

Abstract:

Tumor immunogenic cell death is a type of regulatory cell death, which is driven by stress including chemotherapy drugs, radiotherapy, oncolytic virus, nano carrier drugs and photodynamic force. It can induce specific immune response to tumor death cell antigen. The further study can provide theoretical basis and new ideas for anti-tumor immunity and clinical immunotherapy of tumor.

Key words: Calreticulin, HSC70 heat-shock proteins, HMGB1 protein, Immunogenic cell death