鞣花酸抗消化系统恶性肿瘤的作用机制

doi:10.3760/cma.j.issn.1673-422X.2016.06.020

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (6): 472-474.doi: 10.3760/cma.j.issn.1673-422X.2016.06.020

鞣花酸抗消化系统恶性肿瘤的作用机制

赵金璐，李国东，刘明

150001 哈尔滨医科大学第四临床医学院普外科，普外科生物样本库

收稿日期:2015-11-24 出版日期:2016-06-08 发布日期:2016-04-27
通讯作者: 刘明 E-mail:mliu35@aliyun.com
基金资助:
国家自然科学基金（81372612、81302059）

Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers

Zhao Jinlu, Li Guodong, Liu Ming

Department of General Surgery, BioBank of Department of General Surgery, Fourth Clinical Medical College of Harbin Medical University, Harbin 150001, China

Received:2015-11-24 Online:2016-06-08 Published:2016-04-27
Contact: Liu Ming E-mail:mliu35@aliyun.com
Supported by:
National Natural Science Foundation of China (81372612, 81302059)

摘要/Abstract

摘要： 体内、外实验均证实鞣花酸及其衍生代谢产物能抑制肿瘤细胞增殖、诱导凋亡、阻断DNA损伤诱发的癌变、阻断病毒感染、抑制炎症、抑制血管生成及抑制肿瘤细胞的耐药性等，对消化系统恶性肿瘤细胞生长起到抑制作用。鞣花酸及其衍生代谢产物可能成为抗肿瘤新药。

关键词: 鞣花酸, 消化系统肿瘤, 化学预防, 药理作用分子作用机制

Abstract: Recent in vitro and in vivo experiments have revealed that ellagic acid and its metabolites can inhibit the growth of digestive system malignant tumor cells by inhibiting tumor cell proliferation, inducing apoptosis, breaking DNA binding to carcinogens, blocking virus infection, disturbing inflammation, angiogenesis and drugresistance processes required for tumor metastasis. Ellagic acid and its metabolites are potential chemoprevention and therapeutic drugs against human cancers.

Key words: Ellagic acid, Digestive system neoplasms, Chemoprevention, Molecular mechanisms of pharmacological action

赵金璐，李国东，刘明. 鞣花酸抗消化系统恶性肿瘤的作用机制[J]. 国际肿瘤学杂志, 2016, 43(6): 472-474.

Zhao Jinlu, Li Guodong, Liu Ming. Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers[J]. Journal of International Oncology, 2016, 43(6): 472-474.

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鞣花酸抗消化系统恶性肿瘤的作用机制

Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers

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