国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 299-301.doi: 10.3760/cma.j.issn.1673422X.2016.04.016

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Semaphorin家族与胶质瘤

张海东,张伟,王回,朱广廷   

  1. 272000 山东省医学科学院附属济宁市第一人民医院（张海东、王回、朱广廷）；济南大学山东省医学科学院医学与生命科学学院（张海东）；山东省济宁市第一中学卫生所（张伟）
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 朱广廷，Email: jnyyzgt@163.com E-mail:jnyyzgt@163.com

Semaphorin familily and glioma

Zhang Haidong, Zhang Wei, Wang Hui, Zhu Guangting   

  1. Affiliated Jining First People′s Hospital of Shandong Academy of Medical Sciences, School of Medicine and Life Sciences, University of Ji′nanShandong Academy of Medical Sciences, Jining 272000, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Zhu Guangting E-mail:jnyyzgt@163.com

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摘要： Semaphorin是一类分泌型或结合于细胞表面的轴突导向分子，该家族成员均含有一个由约500个氨基酸残基构成的Sema结构域，这一结构对于其生物学活性的发挥是必需的。研究发现该家族不同成员间的作用各不相同，可发挥癌基因或抑癌基因的作用，与胶质瘤细胞的异常增殖、迁移和侵袭相关，提示可将其作为治疗靶点用于胶质瘤的临床治疗。

关键词: 信号素类, 神经胶质瘤, 细胞运动, 肿瘤侵润

Abstract: Semaphorins act as axon guidance molecules, which were either secretory or binding to the cell surface. All its family members contain a Sema structure, which is composed of about 500 amino acid residues and is essential for its biological activity. Functionally, they play different roles in tumors, such as oncogenes or tumor suppressor genes, and their abnormal expressions are related to the proliferation, migration and invasion of glioma cells. Semaphorins may be the therapeutic targets for the clinical treatment of glioma.

Key words: Semaphorins, Glioma, Cell movement, Neoplasm invasiveness