K-ras基因与结直肠癌疗效

doi:10.3760/cma.j.issn.1673-422X.2014.01.017

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (3): 214-216.doi: 10.3760/cma.j.issn.1673-422X.2014.01.017

K-ras基因与结直肠癌疗效

于法常, 李胜, 牛作兴

250062济南大学山东省医学科学院医学与生命科学学院

出版日期:2014-03-08 发布日期:2014-03-17
通讯作者: 牛作兴，E-mail：nzxsdth@163.com E-mail:nzxsdth@163.com

K-ras gene and colorectal cancer therapeutic effect

YU Fa-Chang, LI Sheng, NIU Zuo-Xing

Ji’nan University Shandong Academy of Medical Sciences Medicine and Life Science; Department of Medicine, Shandong Cancer Hospital, Ji′nan 250062, China

Online:2014-03-08 Published:2014-03-17
Contact: Niu Zuoxing, E-mail: nzxsdth@163.com E-mail:nzxsdth@163.com

摘要/Abstract

摘要： K-ras基因是一种癌基因，促进细胞生长、分化，基因的突变使ras蛋白丧失GTP酶活性，导致细胞的异常生长、分化，促进癌的发生，同时导致使用抗表皮生长因子受体（EGFR）多克隆抗体药物治疗的结直肠癌患者无明显获益。结直肠癌不同实体肿瘤的K-ras基因突变率不同，K-ras基因野生型或突变型对治疗方案选择及预后具有重要意义，突变型患者使用抗EGFR抗体治疗效果差，对5-FU、FOLFOX疗效尚无一致定论。

关键词: 结直肠肿瘤, 治疗结果, K-ras基因

Abstract: K-ras gene is one of oncogenes, which promotes cells growth and differentiation. Ras protein loses the activity of GTP enzyme because of K-ras mutations, and that may cause abnormal growth, differentiation of cells and promote the occurrence of tumor. Patients with colorectal carcinoma that carry mutations in K-ras gene do not benefit from the administration of antiepidermal growth factor receptor (EGFR) polyclonal antibodies. Different solid tumors of colorectal carcinoma have different K-ras mutation rates. Different genotypes of K-ras gene (wildtype or K-ras mutant type) affect significantly on treatment options and prognosis. The efficacy of mutant type patients with antiEGFR antibodies is poor, and the therapeutic effects of 5-FU and FOLFOX are still unclear.

Key words: Colorectal neoplasms, Treatment outcome, K-ras gene

于法常, 李胜, 牛作兴. K-ras基因与结直肠癌疗效[J]. 国际肿瘤学杂志, 2014, 41(3): 214-216.

YU Fa-Chang, LI Sheng, NIU Zuo-Xing. K-ras gene and colorectal cancer therapeutic effect[J]. Journal of International Oncology, 2014, 41(3): 214-216.

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K-ras基因与结直肠癌疗效

K-ras gene and colorectal cancer therapeutic effect

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