东西方前列腺癌的遗传差异

doi:10.3760/cma.j.issn.1673-422X.2014.02.013

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (2): 120-123.doi: 10.3760/cma.j.issn.1673-422X.2014.02.013

东西方前列腺癌的遗传差异

张延玲, 任国平

310003 杭州，浙江大学医学院附属第一医院病理科

收稿日期:2013-09-11 修回日期:2013-12-04 出版日期:2014-02-08 发布日期:2014-01-26
通讯作者: 任国平，E-mail: gpren2002@163.com E-mail:gpren2002@163.com
基金资助:
国家高技术研究发展计划（863计划）项目(2012AA022705)

Genetic differences of prostate cancer between Eastern and Western population

Zhang Yanling, Ren Guoping

Department of Pathology, First Affiliated Hospital of Zhejiang University Medical College, Hangzhou 310003, China

Received:2013-09-11 Revised:2013-12-04 Online:2014-02-08 Published:2014-01-26
Contact: Ren Guoping E-mail:gpren2002@163.com

摘要/Abstract

摘要： 前列腺癌在东西方人群中的发病率和死亡率有明显的种族和地区差异，其主要原因之一是遗传因素。为进一步探索东西方前列腺癌发生发展的不同机制，选取前列腺癌的易感基因RNASEL、ELAC2、PTEN、MSR1及TMPRSS2ERG，并主要以西班牙白种人、非裔美国人、欧洲人及中国人、日本人为代表，比较分析东西方人群基因型及等位基因的分布差异。

关键词: 前列腺肿瘤, 疾病遗传易感性, 基因融合

Abstract: Morbidity and mortality of prostate cancer vary widely between Eastern and Western population, which is mainly due to genetic factors. In order to further explore the different mechanisms of occurrence and development of prostate cancer, the prostate cancer susceptibility genes, such as RNASEL, ELAC2, PTEN, MSR1 and TMPRSS2ERG are selected, and the genotype and allele distribution differences among Hispanic whites, African American, European, Chinese and Japanese are compared.

张延玲, 任国平. 东西方前列腺癌的遗传差异[J]. 国际肿瘤学杂志, 2014, 41(2): 120-123.

Zhang Yanling, Ren Guoping. Genetic differences of prostate cancer between Eastern and Western population[J]. Journal of International Oncology, 2014, 41(2): 120-123.

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东西方前列腺癌的遗传差异

Genetic differences of prostate cancer between Eastern and Western population

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