国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 765-768.

• 综述 • 上一篇    下一篇

癌胚抗原相关黏附分子在肺癌中的作用

王秀秀, 张晓洁, 张华   

  1. 150081 哈尔滨医科大学附属肿瘤医院内六科
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 张华,E-mail:zhanghua07@126.com E-mail:zhanghua07@126.com

Roles of carcinoembryonic antigen-related adhesion molecules in lung cancer

WANG  Xiu-Xiu, ZHANG  Xiao-Jie, ZHANG  Hua   

  1. Sixth Department of Internal Medicine, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: ZHANG Hua, E-mail: zhanghua07@126.com E-mail:zhanghua07@126.com

摘要: 癌胚抗原相关黏附分子(CEACAM)属于免疫球蛋白超家族成员。相关研究表明CEACAM在肺癌发生、发展的过程中发挥着重要的作用,并与肺癌的预后密切相关。近年来,利用单克隆抗体、单域抗体、RNA干扰、基因敲除等技术针对肺癌中CEACAM不同作用靶点的研究取得了一定进展,提示CEACAM将有望成为肺癌诊断中新的生物学标记和治疗靶点。

关键词: font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">癌胚抗原相关黏附分子, 肺肿瘤, 预后

Abstract: Carcinoembryonic antigen-related adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily. Related studies show that  CEACAMs play an critical role in the occurrence and development , and are closely related to the prognosis of lung cancer. Recently, it has made some progresses in the studies by using monoclonal antibodies, single domain antibodies, RNA interference, gene knockout and other technical means targeting different epitopes of CEACAMs in lung cancer, suggesting CEACAMs may become new diagnostic biomarkers and therapeutic targets of lung cancer.

Key words: Carcinoembryonic antigen-related adhesion molecules, Lung neoplasms, Prognosis