国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 593-595.

• 综述 • 上一篇    下一篇

血清KL-6在肺癌放射性肺炎中的研究进展

鲍玲丽, 吴爱兵, 杨志雄   

  1. 524001 湛江，广东医学院附属医院肿瘤中心一区

  • 出版日期:2013-08-08 发布日期:2013-08-15
  • 通讯作者: 杨志雄，E-mail：yangzhixiong068@126.com E-mail:yangzhixiong068@126.com
  • 基金资助:

    广东省科技计划项目（2011B031800324）

KL-6 in radioactive pneumonia with lung cancer

BAO  Ling-Li, WU  Ai-Bing, YANG  Zhi-Xiong   

  1. Departerment of Oncology， Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001，China

  • Online:2013-08-08 Published:2013-08-15
  • Contact: Corresponding author: YANG Zhi-xiong， E-mail:yangzhixiong068@126.com E-mail:yangzhixiong068@126.com

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摘要： 血清KL-6是由上皮性黏蛋白1(MUCl)基因编码的一类糖蛋白，是较早被公认的间质性肺疾病的特异性标志物，而且KL-6亦高表达于部分恶性肿瘤患者。近年的研究发现，血清KL-6与放射性肺炎的发生相关，监测血清KL-6可预测放射性肺炎的发生并评估疾病的严重程度及预后。

关键词: 肺疾病, 间质性, 肺肿瘤, 血清KL-6, 放射性肺炎

Abstract: KL-6 is a category of glycoprotein coded by the epithelium of sticky protein 1 (MUCl) gene, which has a1ready been regarded as an indicator of interstitial lung diseases，and later found highly expressed in part of malignant tumor patients. In recent years, studies has found that serum KL-6 is associated with the incidence of radioactive pneumonia, monitoring serum KL-6 can predict the occurrence of radioactive pneumonia as well assess the severity and prognosis of disease.

Key words: Lung diseases, interstitial, Lung neoplasms, Serum KL-6, Radiation pneumonitis