国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 274-278.

• 综述 • 上一篇    下一篇

代谢酶基因多态性与肺癌易感性

王琪, 胡伟国, 宋启斌   

  1. 430060武汉大学人民医院肿瘤中心
  • 出版日期:2013-04-08 发布日期:2013-03-27
  • 通讯作者: 宋启斌，E-mail：sqb0288@yahoo.com.cn E-mail:sqb0288@yahoo.com.cn

Polymorphisms of metabolic enzymes in relation to susceptibility of lung cancer

WANG  Qi, HU  Wei-Guo, SONG  Qi-Bin   

  1. Tumor Center, Renming Hospital of Wuhan University，Wuhan 430060, China
  • Online:2013-04-08 Published:2013-03-27
  • Contact: SONG Qi-bin E-mail:sqb0288@yahoo.com.cn

PDF

1681

被引次数

4

摘要： 研究表明，肺癌的易感性存在个体差异，参与解毒及生物转化的代谢酶的基因多态性被认为与肺癌易感性相关。催化致癌物质代谢过程的酶主要有Ⅰ相代谢酶和Ⅱ相代谢酶，包括细胞色素P450酶系及由N-乙酰转移酶、微粒体环氧化物酶、二氢烟酰胺腺嘌呤二核苷酸磷酸盐氧化酶（NQO1）等构成的Ⅱ相代谢酶系，这些基因都是预测肺癌易感的候选基因。通过研究代谢酶基因多态性与肺癌易感性的关系，发现有意义的肺癌标志物，筛选肺癌易感人群并提前进行干预，有利于降低肺癌的发病风险。

关键词: 肺肿瘤, 多态现象, 遗传, 疾病易感性

Abstract: It is proved that significant differences in individual susceptibility to lung cancer. Genetic polymorphisms of several enzymes involved in the detoxification and biotransformation might be related to the lung cancer susceptibility. Cytochromes P450, N-acetyltransferases, microsomal epoxide hydrolase, NAD(P)H:quinine oxidoreductase are the most frequently investigated genes in recent years. All theses genes appear to be the candidates for lung cancer susceptibility genes. The studies of the relationship between polymorphisms of metabolic enzymes and lung cancer susceptibility will help to find useful biomarkers. An improved understanding of genetic polymorphisms may help to identify individuals who are at increased risk for lung cancer and decrease the incidence of lung cancer.

Key words: Lung neoplasms, Polymorphism, genetic, Disease susceptibility