国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 163-165.

• 综述 •    下一篇

STAT蛋白参与树突状细胞中IDO转录调控的研究进展

王越, 于津浦, 任秀宝   

  1. 300060 天津医科大学附属肿瘤医院免疫室 天津市肿瘤防治重点实验室
  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 基金资助:

    国家自然科学基金（81072159）；天津市高等学校科技发展基金（20090133）

Mechanisms of STAT family mediated IDO regulation in dendritic cells

WANG  Yue, YU  Jin-Pu, REN  Xiu-Bao   

  1. Department of Immunology, Affiliated Cancer Hospital of Tianjin Medical University, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China
  • Online:2013-03-08 Published:2013-02-25

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1396

被引次数

4

摘要： 吲哚胺2,3双加氧酶（IDO）被认为是一种重要的内源性免疫抑制酶。越来越多的研究证实IDO在肿瘤的发生发展中扮演十分重要的角色，肿瘤细胞不仅自身能表达IDO，而且还吸引树突状细胞（DC）表达IDO，参与肿瘤免疫耐受的形成。信号转导子与转录激活子家族(STAT)是参与树突状细胞中IDO转录调控的主要信号蛋白家族，详细阐明DC中STAT蛋白对IDO表达的调控机制对于肿瘤治疗很有必要，将会帮助我们开发特异性更强、活性更高的IDO特异性抑制剂，并为抗肿瘤靶向治疗提供新的选择。

关键词: 反式激活（遗传学）, 细胞因子信号转导蛋白抑制分子, 树突细胞, 吲哚胺2,3双加氧酶

Abstract: Indoleamine 2, 3-dioxygenase (IDO) is known as an endogenous immunosuppressive enzyme which plays a significant role in the process of tumor. IDO is not only found in tumor cells but also detected in dendritic cell (DC) in tumor microenvironment, which participates in the formation of tumor immune tolerance through expressing IDO enzyme. Signal transducer and activator of transcription (STAT) is the main signal protein family which participates in the IDO transcriptional regulation of DC.It is necessary to detail the signaling pathway in regulating IDO expression, which will help us develop high specific andmore active IDO inhibitors and provide new options for anti-cancer targeted therapy.

Key words: Trans-activation(genetics), Supressor of cytokine signaling proteins, Dendritic cells, Indoleamine 2, 3-dioxygenase