国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 126-130.

• 综述 • 上一篇    下一篇

核苷酸切除修复通路基因多态性与肺癌易感性

钱莹莹, 束永前   

  1. 210029  南京医科大学第一附属医院肿瘤科
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 束永前，E-mail:shuyongqian@csco.org.cn E-mail:shuyongqian@csco.org.cn

Gene polymorphisms in the nucleotide excision repair pathway and lung cancer susceptibility

QIAN  Ying-Ying, SHU  Yong-Qian   

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: SHU Yong-qian, E-mail: shuyongqian@csco.org.cn E-mail:shuyongqian@csco.org.cn

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摘要： 核苷酸切除修复(NER)通路是修复DNA损伤的主要途径之一，其中着色性干皮病A型(XPA)基因、核苷酸切除修复交叉互补1（ERCC1）基因和着色性干皮病D型(XPD)基因的单核苷酸多态性（SNP）改变了NER通路中重要酶与蛋白的修复功能，引起DNA损伤修复能力的差异，最终导致个体肺癌易感性不同。

关键词: 肺肿瘤, 核苷酸切除修复通路, 多态性, 单核苷酸, 疾病易感性

Abstract: Nucleotide excision repair (NER) pathway is one of the principal ways of the repair of DNA damage. The single nucleotide polymorphisms (SNP) of its key genes such as xeroderma pigmentosum group A (XPA) gene, excision repair cross complementing1 (ERCC1) gene and xeroderma pigmentosum group D (XPD) gene may be associated with differences in the DNA repair capacity and may influence an individual’s risk of lung cancer, because the variant genotype in those polymorphisms might destroy or alter repair function.

Key words: Lung neoplasms, Nucleotide excision repair pathway, Polymorphisms, single nucleotide, Disease susceptibility