国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 778-781.

• 综述 • 上一篇    下一篇

妇科肿瘤患者的激素替代治疗

王祎晨,徐小仙,沈艳敏,于爱军   

  1. 310022 杭州,浙江省肿瘤医院妇瘤科（王祎晨、徐小仙、于爱军）；浙江医院妇产科（沈艳敏）
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 于爱军，E-mail: yaj1993@126.com E-mail:yaj1993@126.com

Hormone replacement therapy for gynaecological cancer

 WANG  Yi-Chen, XU  Xiao-Xian, SHEN  Yan-Min, YU  Ai-Jun   

  1. Department of Gynecological Oncology， Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: YU Ai-jun， E-mail: yaj1993@126.com E-mail:yaj1993@126.com

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摘要： 妇科肿瘤年轻患者经治疗后常因卵巢功能衰退提前出现绝经综合征，其最有效的治疗方法是激素替代治疗（HRT）。根据目前的研究，HRT不增加早期子宫内膜癌、子宫平滑肌肉瘤复发及死亡风险；对卵巢癌患者的安全性尚无定论；宫颈鳞癌、阴道癌和外阴癌不是HRT的禁忌证；但雌激素替代治疗（ERT）是低度恶性子宫内膜间质肉瘤的禁忌。对有严重绝经综合征的患者，可综合评估风险，与患者充分沟通后使用HRT以提高生活质量。

关键词: 激素替代疗法, 绝经, 生殖器肿瘤, 女（雌）性

Abstract: Treatment of gynaecological cancer frequently results in the loss of ovarian function and menopausal syndrome. The most effective treatment is hormone replacement therapy (HRT). According to the current studies, HRT does not increase the risk of recurrence or death in patients with early stage endometrial cancer and uterine leiomyosarcomas. The safety of HRT in ovarian cancer patients is inconclusive. Cervical squamous cell carcinoma, vaginal cancer and vulvar cancer are not contraindications for HRT. Estrogen replacement therapy（ERT） is contraindicated for lowgrade endometrial stromal sarcomas. Therefore, after integrated risk assessment and discussion, patients with severe menopausal symptoms can be treated with HRT to improve the quality of life. 

Key words: Hormone replacement therapy, Menopause, Genital neoplasms, female