关键词: 食管肿瘤, 癌, 小细胞, 肿瘤标记, 生物学

Abstract: Primary esophageal small cell carcinoma (PESC) is a rare form of esophageal carcinoma which is with high degree of malignancy and early metastasis. Although the histological origin and etiology of PESC remains to largely unknown, one attractive viewpoint is that it derives from original pluripotent stem cells of esophageal mucosa. PESC have both epithelium and neuroendocrine cellular features. Neuroendocrine biomarkers including NES and Syn have been used for identification of PESC.