国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (12): 900-902.

• 综述 • 上一篇    下一篇

泛素特异性蛋白酶9X与肿瘤

杨波, 谢丛华   

  1. 400070广州军区武汉总医院肿瘤科
  • 出版日期:2011-12-08 发布日期:2011-11-25
  • 通讯作者: 谢丛华,E-mail:chxie_65@hotmail.com E-mail:chxie_65@hotmail.com
  • 基金资助:

    国家自然科学基金资助项目 81071908

Ubiquitin specific peptidase 9X and tumor

YANG  Bo, XIE  Cong-Hua   

  1. Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, Wuhan 430070 China
  • Online:2011-12-08 Published:2011-11-25

摘要: 泛素特异性蛋白酶在调节蛋白酶体的活性、器官的发生、肿瘤的形成以及转录调控等方面都具有重要的作用。其中,泛素特异性蛋白酶9X(USP9X)通过去泛素化底物蛋白,影响肿瘤细胞增殖、黏附和信号转导,是肿瘤演进的重要因素之一。

Abstract: Ubiquitin specific peptidases play important roles in controlling proteasome activity, organogenesis, tumorigenesis and transcriptional regulation. Ubiquitin specific peptidase 9X is able to remove ubiquitin from substrate proteins, so it may effectively regulate the proliferation, adhesion and signal transduction of tumor cells. It is a one of the most important factors in tumor progression.