国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (12): 897-900.

• 综述 • 上一篇    下一篇

磷脂酶A2与肿瘤

张霞, 王杰军   

  1. 200003 上海第二军医大学长征医院肿瘤科
  • 出版日期:2011-12-08 发布日期:2011-11-25
  • 通讯作者: 王杰军，E-mail: jiejunw@csco.com.cn E-mail:jiejunw@csco.com.cn

Phospholipase A2 and Cancer

ZHANG  Xia, WANG  Jie-Jun   

  1. Department of Oncology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
  • Online:2011-12-08 Published:2011-11-25

PDF

1622

摘要： 磷脂酶A2（PLA2）是由不同结构和功能的酶组成的，这些酶具有水解磷脂Sn-2位酯键的能力。近年来研究显示，PLA2的多种亚型在肿瘤中表达异常，且与肿瘤增殖、凋亡、侵袭、转移和预后密切相关，不同的亚型在肿瘤中的作用也不相同。对PLA2的研究可为肿瘤的治疗提供新思路。

Abstract: Phospholipase A2 (PLA2) is consisted of a large group of enzymes, which can hydrolyze Sn-2 ester bond of the phospholipids and have different structures and functions. According to the latest related researches, many subtypes of PLA2 express abnormally in a various of tumors and have a close relationship with cancer proliferation， apoptosis，invasion， metastasis and prognosis. Different subtypes have different effects on neoplasms. PLA2 can supply a new insight on cancer therapy.