国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (10): 627-630.doi: 10.3760/cma.j.issn.1673-422X.2019.10.013

• 综述 • 上一篇    下一篇

立体定向体部放疗在晚期肾癌治疗中的应用

 蔡梁,沈亚丽   

  1. 1四川大学华西医院肺癌中心，成都610041；2四川大学华西医院腹部肿瘤科，成都610041

  • 出版日期:2019-10-08 发布日期:2019-12-22
  • 通讯作者: 沈亚丽，Email: sylprecious@163.com E-mail: sylprecious@163.com
  • 基金资助:

    四川省科技计划（2019YJ0142）

Application of stereotactic body radiation therapy in advanced renal cell carcinoma

Cai Liang1, Shen Yali2   

  1. 1Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; 2Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China

  • Online:2019-10-08 Published:2019-12-22
  • Contact: Shen Yali, Email: sylprecious@163.com E-mail: sylprecious@163.com
  • Supported by:

    Science and Technology Plan of Sichuan Province of China (2019YJ0142)

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摘要：

立体定向体部放疗（SBRT）可通过缺氧诱导因子-1α及酸性鞘磷脂酶等生物因子有效杀伤肾癌细胞。较高生物剂量及单次照射的SBRT方案能够使晚期肾癌原发灶及转移灶得到更有效的局部控制，并且不良反应可耐受。SBRT与靶向药物联合治疗可增强肾癌对放疗的敏感性，SBRT与免疫药物联合治疗可通过远隔效应增强免疫反应。SBRT在晚期肾癌治疗相关的疗效，仍需进一步探索。

关键词:

肾肿瘤, 肿瘤晚期, 立体定向体部放疗

Abstract:

Stereotactic body radiation therapy (SBRT) can effectively kill renal cancer cells by biological molecules such as hypoxia-inducible factor-1α and acid sphingomyelinase. SBRT regimen with higher biological dose and single irradiation can achieve more effective local control of primary and metastatic lesion of advanced renal cancer, and adverse reactions can be tolerated. Combination of SBRT and targeted drugs can increase the sensitivity of renal cancer to radiotherapy, and the combination of SBRT and immune drugs can enhance the immune response through the abscopal effect. The efficacy of SBRT in the treatment of advanced renal cancer remains to be explored.

Key words:

Kidney neoplasms, Advanced tumor, Stereotactic body radiation therapy