国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (10): 620-623.doi: 10.3760/cma.j.issn.1673-422X.2019.10.011

• 综述 • 上一篇    下一篇

lncRNA与小细胞肺癌

 明超1,何锐1,孙远1,田翎含2,赵光强1   

  1. 1昆明医科大学第三附属医院 云南省肿瘤医院胸外一科650100； 2昆明医科大学第三附属医院 云南省肿瘤医院肿瘤研究所650100

  • 出版日期:2019-10-08 发布日期:2019-12-22
  • 通讯作者: 赵光强，Email: zgqst2012@163.com E-mail: zgqst2012@163.com
  • 基金资助:

    国家自然科学基金（81702274）；云南省卫生科技计划（2018NS0071）；云南省卫生和计划生育委员会医学学科带头人培养计划（D-2017012）；云南省科技计划［2017FE467（-074）］

lncRNA and small cell lung cancer

Ming Chao1, He Rui1, Sun Yuan1, Tian Linghan2, Zhao Guangqiang1   

  1. 1First Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650100, China; 2Cancer Research Institute, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital， Kunming 650100, China 

  • Online:2019-10-08 Published:2019-12-22
  • Contact: Zhao Guangqiang, Email: zgqst2012@163.com E-mail: zgqst2012@163.com
  • Supported by:

    National Natural Science Foundation of China (81702274); Health Science and Technology Plan Project of Yunnan Province of China (2018NS0071); Health and Family Planning Commission Medical Discipline Leadership Program of Yunnan Province of China (D-2017012); Technology Plan Project of Yunnan Province of China ［2017FE467（-074)］

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摘要：

肺癌发病率及死亡率居首位，小细胞肺癌(SCLC)约占肺癌病例的15%。近年来研究发现长非编码RNA (lncRNA)(TUG1、CCAT2、PVT1、HOTTIP和HOTAIR)在SCLC的发生发展中具有一定的作用，lncRNA可在转录中、转录后和表观遗传学水平上调控相关基因水平的表达，从而影响SCLC的增殖、侵袭、转移及化疗耐药。

关键词:

小细胞肺癌； RNA, 长链非编码

Abstract:

The incidence and mortality of lung cancer rank first, and small cell lung cancer (SCLC) accounts for about 15% of lung cancer cases. In recent years, it has been found that long non-coding RNA (lncRNA) (TUG1, CCAT2, PVT1, HOTTIP and HOTAIR) plays a significant role in the development of SCLC. lncRNA can regulate the expression of related genes at the transcriptional, posttranscriptional and epigenetic levels, and it can infulence proliferation, invasion, metastasis and chemotherapy resistance of SCLC. 

Key words:

Small cell lung carcinoma, RNA, long noncoding