国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 689-692.

• 综述 • 上一篇    下一篇

PTEN与胃癌

王思家, 李连宏   

  1. 116044大连,大连医科大学七年制(王思家),病理学与法医学教研室(李连宏)
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 李连宏,E-mail: lilianhong@dlmedu.edu.cn E-mail:lilianhong@dlmedu.edu.cn

PTEN and gastric cancer

WANG  Si-Jia, LI  Lian-Hong   

  1. Seven-year Program of Dalian Medical University, Dalian 116044, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Correspongding author: LI Lian-hong, E-mail:lilianhong@dlmedu.edu.cn E-mail:lilianhong@dlmedu.edu.cn

摘要: 胃癌的发生发展是一个多因素、多基因、多阶段、多途径有序的过程。人第10号染色体缺失的磷酸酶及张力蛋白同源的基因(PTEN)是迄今为止发现的第一个具有双重特异性磷酸酶活性的抑癌基因,调控着细胞周期和多种信号途径,在胃癌的发生发展中起重要作用。关于PTEN的进一步研究将为胃癌诊断、治疗及判断预后提供新的思路。

关键词: 基因, 肿瘤抑制, 胃肿瘤, 人第10号染色体缺失的磷酸酶及张力蛋白同源的基因

Abstract: The development and progression of gastric cancer is a multi-factor, multi-gene, multi-stage and multi-approach sequential process. PTEN is so far the first discovery of a dual specificity phosphatase activity of the tumor suppressor gene, which regulates the cell cycle and multiple signaling pathways of gastric cancer and plays an important role in the development and progression of gastric cancer. Further studies on PTEN will provide a new way for the early diagnosis, treatment and prognosis of gastric cancer.

Key words: Genes, tumor suppressor, Stomach neoplasms, PTEN