国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 797-800.

• 论著 • 上一篇    

BRAF基因突变与皮肤黑色素瘤临床病理特征关系的meta分析

杨猛, 邝晓聪, 潘延斌, 等   

  1. 530000南宁，广西医科大学研究生学院（杨猛、程秋梅），病理生理教研室（邝晓聪），广西医科大学第三附属医院皮肤科（潘延斌、谭美乐、卢斌珠、卢坚、李建民）
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 李建民，E-mail：4830380@163.com E-mail:4830380@163.com
  • 基金资助:

    广西壮族自治区科技厅基金（桂科政1140003B-86）

Frequencies of BRAF mutations in clinical Pathology of cutaneous melanoma: a meta-analysis

YANG  Meng, KUANG  Xiao-Cong, PAN  Yan-Bin, DENG    

  1. Postgraduate School of Guangxi Medical University, Nanning 530000, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: Li Jian-min, E-mail: 4830380@163.com E-mail:4830380@163.com

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摘要： 目的  探讨BRAF突变频率以及该突变与皮肤黑色素瘤(CM)临床病理特征的关系。方法  全面检索相关文献，采用Revman5.0软件进行统计分析。结果  涉及BRAF突变有9项研究，共1134例患者。CM患者BRAF突变率为47.3%。50岁以上患者BRAF突变OR=2.30，95%CI为1.36～3.91；浅表扩散性黑色素瘤(SSM )BRAF突变OR =2.11，95%CI为1.64～2.71；病灶在躯干时BRAF基因突变OR =2.35，95% CI为1.71～3.21；浸润深度小于1 mm时BRAF突变OR =1.56，95% CI为1.08～2.25。结论  BRAF基因突变易发生于年龄50岁以上、SSM、病灶在躯干及浸润深度小于1 mm的患者，而与性别无关。

关键词: 突变, 黑色素瘤, Meta分析, BRAF

Abstract: Objective  To explore the frequencies of BRAF mutations and the relationship between BRAF mutations and clinicopathological features of CM. Methods We search relevant literatures and the meta-analysis were conducted by Revman5.0 software. Results  9 studies were involved of BRAF mutations and 1134 patients are included. BRAF mutations are 47.3% of CM;As for patients over 50 years old, the OR of BRAF mutations is 2.30, 95% CI 1.36~3.91; the OR of BRAF mutations for SSM is 2.11, 95% CI 1.64~ 2.71; the OR of BRAF mutations for lesions in the trunk is 2.35, 95% CI 1.71~3.21; the OR of BRAF mutations for invasion depth less than 1mm is1.56, 95%CI 1.08~2.25. Conclusion mutations are more frequent in patients over 50 years old, in SSM and in patients whose lesions in the truck and invasion depth less than 1mm .They have no relationship with sex.

Key words: Mutation, Melanoma, Meta-analysis, BRAF