国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (2): 143-148.
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马冬华, 张亮, 王亚旭
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MA Dong-Hua, ZHANG Liang, WANG Ya-Xu
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摘要： 磷脂酰肌醇3激酶-蛋白激酶B（PI3K-Akt）通路异常激活已经被证实与多种肿瘤发生发展密切相关，并且PI3K-Akt通路在结肠癌的发生发展中起重要作用，它参与调控结肠肿瘤细胞存活和增殖、抑制凋亡、促进细胞周期进程等，并且抑制该通路还可能在结肠癌治疗中有潜在作用。
Abstract: The abnormal activation of phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt) pathway has already been confirmed that it is closely related to the origin and development of various tumors. PI3K-Akt pathway plays an important role in development of colon cancer, it can regulate cell survival, proliferation, anti-apoptosis, cell cycle progression, etc. Furthermore, inhibition of this pathway may play a potential roll in oncotherapy.
马冬华, 张亮, 王亚旭. 磷脂酰肌醇3激酶-蛋白激酶B信号通路在结肠癌中的作用[J]. 国际肿瘤学杂志, 2012, 39(2): 143-148.
MA Dong-Hua, ZHANG Liang, WANG Ya-Xu. The effect of phosphatidylinositol-3-kinase -protein kinase B signal pathway in colon cancer[J]. Journal of International Oncology, 2012, 39(2): 143-148.
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