国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (11): 876-878.

• 论著 • 上一篇    

八聚体转录因子4蛋白表达与非肌层浸润性膀胱癌的关系

蒋海锋, 张连华, 薄隽杰, 等   

  1. 200001 上海交通大学医学院附属仁济医院泌尿外科
  • 出版日期:2011-11-08 发布日期:2011-11-03
  • 通讯作者: 薄隽杰，E-mail:bojuanjie@yahoo.com.cn E-mail:bojuanjie@yahoo.com.cn
  • 基金资助:

    上海市自然科学基金资助项目（09ZR1418000）

The expression of Oct4 protein in non-muscle-invasive bladder cancer

JIANG  Hai-Feng, ZHANG  Lian-Hua, BAO  Juan-Jie, et al   

  1. Department of Urology，Renji hospita1，School of Medicine，Shanghai Jiao Tong University，Shanghai 200127，China
  • Online:2011-11-08 Published:2011-11-03

PDF

1555

摘要： 目的 探讨八聚体转录因子4（Oct4）蛋白在非肌层浸润性膀胱癌中的表达情况，并分析其表达与患者临床病理特征及预后的关系。方法 采用免疫组化生物素酶标法检测87例非肌层浸润性膀胱移行细胞癌和15例癌旁正常组织中Oct4蛋白的表达情况，并结合临床资料分析Oct4蛋白的表达在膀胱癌患者中的意义。结果 正常组织中Oct4蛋白的表达水平明显低于肿瘤组织（P<0.01）。G1级、G2级、G3级膀胱癌的Oct4蛋白阳性表达率分别为40.7%、69.4%、91.7%，差异有统计学意义（P<0.01）。所有患者随访3~78个月，其中63例出现复发，复发组与未复发组中Oct4蛋白的阳性表达率分别为77.8%和37.5%，差异有统计学意义（P<0.01）；21例复发患者出现进展，进展组与未进展组中Oct4蛋白的阳性表达率分别为71.4%和65.2%，差异无统计学意义（P>0.05）。Oct4蛋白的表达与患者的年龄、性别、肿瘤的数目及大小无明显相关性（P>0.05）。结论 Oct4蛋白检测有助于早期发现膀胱肿瘤，并可用来判断肿瘤的恶性分化程度及检测患者术后的复发情况。

Abstract: Objective To investigate the expression of Oct4 protein and analyze the clinic pathological features and prognosis in non-muscle-invasive bladder cancer. Methods Oct4 protein expression was assessed by immunohistochemical analysis of 87 specimens of bladder transitional cell carcinoma and 15 specimens of adjacent normal tissues. A correlation between Oct4 and clinic pathological features was analyzed. Results The positive rate of Oct4 protein was significantly higher in bladder cancer than that in normal bladder tissue（P<0.01）. The positive rate of Oct4 protein was 40.7% in G1 bladder cancer, 69.4% in G2 bladder cancer and 91.7% in G3 bladder cancer, of which the differences was significant (P<0.01). All patients were followed up for 3-78 months, and 63 of them relapsed. The expression of Oct4 protein was significantly higher in patients of recurrence than in non-recurrence (77.8%vs.37.5%, P<0.01). 21 patients of recurrence were in progression, and the expression of Oct4 protein had no significant differences between patients of progression and non-progression (71.4%vs65.2%, P>0.05). The positive rate of Oct4 protein was not related with sex, age, tumor number and size (P>0.05). Conclusion The detection of Oct4 protein is in favor of early detection of bladder tumor, estimation the degree of differentiation and surveillance for recurrence of superficial bladder cancer.