国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (11): 819-822.

• 综述 • 上一篇    下一篇

内皮单核细胞活化多肽Ⅱ与肿瘤

谭家余, 黄湘   

  1. 528403 广东省中山市博爱医院中心ICU（谭家余），产前诊断中心（黄湘）
  • 出版日期:2011-11-08 发布日期:2011-11-03

Endothelial monocyte-activating polypeptide-Ⅱand tumor

TAN  Jia-Yu, HUANG  Xiang   

  1. Central ICU of Bo’ai Hospital of Zhongshan City, Zhongshan 528403, China
  • Online:2011-11-08 Published:2011-11-03

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摘要： 皮单核细胞活化多肽Ⅱ（EMAP-Ⅱ）是一个致炎细胞因子，具有致炎、促凋亡和抗血管生成特性。EMAP-Ⅱ与肿瘤坏死因子、血管内皮生长因子、低氧诱导因子1α、精氨酰-tRNA合成酶和胰岛素样生长因子-Ⅰ等多种肿瘤相关蛋白相互作用。EMAP-Ⅱ具有抗肿瘤特性，在肿瘤防治中具有应用前景。

Abstract: Endothelial monocyte-activating polypeptide-Ⅱ (EMAP-Ⅱ) is a novel proinflammatory cytokine with proinflammatory, proapoptotic and antiangiogenic properties. It is associated with many tumor-associated proteins, such as tumor necrosis factor, vascular endothelial growth factor, hypoxia inducible factor-1α, arginyl-tRNA synthetase, and insulin-like growth factor-Ⅰ. EMAP-Ⅱ has anti-tumor properties and has a good prospect in cancer prevention and treatment.