国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (11): 816-818.

• 综述 • 上一篇    下一篇

胰岛素-胰高血糖素瘤克隆20在肿瘤细胞中的作用

魏玉平, 董亮, 毕文祥   

  1. 250012 济南，山东大学医学院生物化学与分子生物学研究所（魏玉平、毕文祥）；山东大学齐鲁医院呼吸内科（董亮）
  • 出版日期:2011-11-08 发布日期:2011-11-03

Effects of insulinoma-glucagonoma clone 20 isoforms on cancer cells

WEI  Yu-Ping, DONG  Liang, BI  Wen-Xiang   

  1. Department of Biochemistry and Molecular Biology of Medical School, Shandong University, Jinan 250012，China
  • Online:2011-11-08 Published:2011-11-03

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摘要： 胰岛素-胰高血糖素瘤克隆20（IG20）在人类细胞中至少可表达6种剪接异型体，这些蛋白主要通过细胞肿瘤坏死因子（TNF）与TNF相关死亡配体（TRAIL）等凋亡相关的信号通路来影响细胞的凋亡与增殖，此外其还作为GTP-GDP交换因子参与神经突触囊泡蛋白的运输。

Abstract: Insulinoma-glucagonoma clone 20 can express at least 6 isoforms in human cells. These isoforms can affect cell apoptosis and proliferation through apoptosis related signaling pathway, such as TRAIL or TNF signaling pathways. Furthermore, insulinoma-glucagonoma clone 20, as a GTP-GDP exchange factor, participates in the transportation of nerve synaptophysins.