国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (11): 813-815.

• 综述 • 上一篇    下一篇

髓源性抑制细胞介导的免疫抑制研究进展

杨宝宏, 于津浦, 任秀宝   

  1. 300060 天津医科大学附属肿瘤医院肿瘤研究所
  • 出版日期:2011-11-08 发布日期:2011-11-03

Myeloid derived suppressor cells mediated suppress immunity

YANG  Bao-Hong, YU  Jin-Pu, REN  Xiu-Bao   

  1. Tianjin Key Laboratory of Tumor Prevention and Treatment,Department of Caner Biotherapy,Tumor Hospital of Tianjin Medical University,Tianjin 300060,China
  • Online:2011-11-08 Published:2011-11-03

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摘要： 肿瘤患者体内积聚的一类髓系细胞与肿瘤免疫逃逸密切相关，称为髓源性抑制细胞(MDSC)。在肿瘤患者体内血液、淋巴结以及骨髓中也存在着一群MDSC，对固有免疫系统和适应性免疫系统有抑制作用,髓样抑制细胞通过多条途径发挥免疫抑制作用。通过减少患者体内MDSC的数量或抑制MDSC相关的免疫抑制作用通路，在肿瘤治疗中将是很有前景的免疫治疗方法。

Abstract: There exists a population of myeloid-origin cells that are associated with tumor immune escape in cancer patients,commonly termed as myeloid derived suppressor cells(MDSCs). MDSCs accumulate in the blood,lymph nodes,bone marrow, and inhibit both adptive and innate immunity.Different suppressive mechanisms are used by MDSCs to block tumor immunity. Reducing the numbers of MDSCs or inhibiting the suppressive pathway conducted by MDSCs will bring new highlight to biotherapy in tumor treatment.