质子治疗横纹肌肉瘤的研究进展

doi:10.3760/cma.j.issn.1673-422X.2017.07.020

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (7): 554-556.doi: 10.3760/cma.j.issn.1673-422X.2017.07.020

质子治疗横纹肌肉瘤的研究进展

李祎，张秋宁，王小虎

730000 兰州大学第一临床医学院研究生院（李祎、张秋宁）；甘肃省医学科学院肿瘤医院放疗科（李祎、张秋宁、王小虎）

收稿日期:2016-11-17 出版日期:2017-07-08 发布日期:2017-06-20
通讯作者: 王小虎 E-mail:xhwanggansu@163.com
基金资助:
国家自然科学基金(81372419)

Research progress of proton therapy in rhabdomyosarcoma

Li Yi, Zhang Qiuning, Wang Xiaohu

Graduate School of First Clinical Medical College of Lanzhou University, Lanzhou 730000, China

Received:2016-11-17 Online:2017-07-08 Published:2017-06-20
Contact: Wang Xiaohu E-mail:xhwanggansu@163.com
Supported by:
National Natural Science Foundation of China (81372419)

摘要/Abstract

摘要： 横纹肌肉瘤（RMS）是儿童最常见的软组织肉瘤。放疗已成为RMS治疗的首选治疗方案之一，但可诱发严重的急性和晚期不良反应。质子治疗近年来越来越多的被应用于治疗RMS中。质子治疗安全有效，无严重不良反应。与常规射线比较，质子治疗RMS有物理学优势，可以更好地降低正常组织的受照剂量，提高患者生命质量。仍需要更多前瞻性研究和长期随访的临床结局，明确质子治疗应用于治疗RMS是否在晚期并发症的发生率和严重程度等方面优于光子治疗。

关键词: 横纹肌肉瘤, 儿童, 质子治疗

Abstract: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood. Radiation therapy has been integrated into the primary treatment of most patients with rhabdomyosarcoma, but which in turn potentially induces severe acute and late toxicities. Proton therapy in recent years has been more and more used in the treatment of rhabdomyosarcoma, which is safe and effective, with no serious adverse events. Compared with conventional photon therapy, proton therapy has distinct physical advantages and enables greater precision in the delivery of tumoricidal radiation doses with reduced irradiation of normal tissues, and improves quality of life for patients. Additional followup and prospectively studies are needed to determine whether proton therapy truly reduces the incidence and severity of late effects in comparison to patients treated with modern photon techniques.

Key words: Rhabdomyosarcoma, Child, Proton therapy

李祎，张秋宁，王小虎. 质子治疗横纹肌肉瘤的研究进展[J]. 国际肿瘤学杂志, 2017, 44(7): 554-556.

Li Yi, Zhang Qiuning, Wang Xiaohu. Research progress of proton therapy in rhabdomyosarcoma[J]. Journal of International Oncology, 2017, 44(7): 554-556.

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质子治疗横纹肌肉瘤的研究进展

Research progress of proton therapy in rhabdomyosarcoma

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