Pygopus研究进展

doi:10.3760/cma.j.issn.1673422X.2015.05.012

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (5): 364-366.doi: 10.3760/cma.j.issn.1673422X.2015.05.012

Pygopus研究进展

厦门大学附属第一医院神经外科

出版日期:2015-05-08 发布日期:2015-05-12
通讯作者: 王占祥 wangz@xmbrain.com
基金资助:
国家自然科学基金（81271332）；福建省自然科学基金（2009D002）

Recent advance in Pygopus

Department of Neurosurgery, First Affiliated Hospital of Xiamen University

Online:2015-05-08 Published:2015-05-12
Contact: Wang Zhanxiang wangz@xmbrain.com

摘要/Abstract

摘要： Pygopus（Pygo）是Wnt信号通路中新发现的成员，位于该信号通路核心蛋白β连接蛋白（βcatenin）下游，可介导βcatenin入核，激活下游靶基因转录。Pygo对哺乳动物的胚胎发育及肿瘤的形成起着重要的作用。研究表明，Pygo通过组蛋白解读、组蛋白修饰等表观遗传学机制调控干细胞、肿瘤细胞、肿瘤干细胞。阐述Pygo蛋白在其中的作用及机制，将会加深对与该蛋白相关肿瘤的认识。

关键词: 肿瘤干细胞/后成说, 遗传/Pygopus

Abstract: Pygopus (Pygo) is a new discovered component of Wnt signaling, which is located in the downstream of its core protein βcatenin and can mediate βcatenin into nucleus and activate target gene transcription. Pygo plays an important role in mammalian embryonic development and tumor formation. Recent studies show that Pygo regulates stem cells, tumor cells and tumor stem cells by epigenetic mechanisms such as histone interpretations and modifications. Further insights into Pygo's functions and mechanisms will extend our knowledge of the Pygorelated tumors.

李明聪, 王占祥. Pygopus研究进展[J]. 国际肿瘤学杂志, 2015, 42(5): 364-366.

LI Ming-Cong, WANG Zhan-Xiang. Recent advance in Pygopus[J]. Journal of International Oncology, 2015, 42(5): 364-366.

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Pygopus研究进展

Recent advance in Pygopus

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