Mechanisms of hypoxia triggering tumor development

Abstract

Abstract: High-altitude hypoxia is closely associated with cancer initiation and progression. Hypoxia promotes tumor development through multiple mechanisms including modifying acidic microenvironment, triggering tumor angiogenesis, influencing vasculogenic mimicry, inducing epithelial-mesenchymal transition, remodeling of extracellular matrix, promoting immune escape and adaptive landscapes, maintaining cancer stem cells and inhibiting senescence. Targeting hypoxia may become a novel efficient strategy for cancer therapy.

Key words: font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Neoplasmsfont-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体">Anoxia

ZHANG Bai-Hong. Mechanisms of hypoxia triggering tumor development[J]. Journal of International Oncology, 2012, 39(2): 108-110.

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Mechanisms of hypoxia triggering tumor development

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