Abstract: The Hedgehog (Hh) signaling pathway plays a central important role during embryo development of vertebrate, which participates in regulation of multiplebasic life processes including cell proliferation, differentiation and tissue patterning. In normal adult physiology, the pathway is implicated in stem cell maintenance, tissue repair and regeneration. By now, more and more researches have been indicated that the Hh signaling pathway is related to the tumor growth promoting and survival capabilities.