Journal of International Oncology

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (2): 92-95.

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Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer

HUANG  Fan, LI  Yuan, PENG  Ming-Qing   

  1. Central Laboratory, Yongchuan Hospital, Chongqing Medical University,Chongqing 402160, China
  • Online:2012-02-08 Published:2012-01-18
  • Contact: Corresponding author: LI Yuan, E-mail: liyuan_1985999@163.com E-mail:liyuan_1985999@163.com

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Abstract: Expression and regulation of the P-glycoprotein (P-gp) is associated with the development of multidrug resistance in cancer. Cancer cells are exposed in endogenous damages from its own micro-environments and inflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significance for exploring the multidrug resistance of cancer cell.

Key words: font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">Neoplasms, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">P-glycoprotein,  Drug resistance, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-bidi-font-size: 10.5pt">Signal transduction