Abstract: Efficacy of chemotherapy for advanced gastric cancer was unsatisfactory. Molecular targeted therapies have emerged as a novel approach to the treatment of advanced gastric cancer in recent years. These therapeutic strategies include targeting EGFR signal transduction pathway, anti-angiogenesis therapy, multi-target molecular targeted drugs. Targeted drugs such as trastuzumab, cetuximab, bevacizumab, apatinib, sorafenib sunitinib, lapatinib and everolimus which are targeting HER2, EGFR, VEGF and mTOR pathway, are applied in the comprehensive treatment of advanced gastric cancer, and their therapeutic effects are encouraging.