Abstract: Phospholipase A2 (PLA2) is consisted of a large group of enzymes, which can hydrolyze Sn-2 ester bond of the phospholipids and have different structures and functions. According to the latest related researches, many subtypes of PLA2 express abnormally in a various of tumors and have a close relationship with cancer proliferation， apoptosis，invasion， metastasis and prognosis. Different subtypes have different effects on neoplasms. PLA2 can supply a new insight on cancer therapy.