Abstract: Recent findings indicate that metastasis-associated gene in colon cancer 1  (MACC1) has an abnormal high expression in most malignant tumors. As a key regulator of HGF-MET signal pathway, MACC1 could obviously up-regulate the expression of MET and promote cancer cell’s movement, invasion and metastasis. Further studies will shed light on elucidating the mechanisms of metastasis and may provide a new method for targeted therapy.