Abstract: Dendritic cells (DC) are the important auxiliary cells in tumor vaccines to activate antitumor immunity. Suppressor of cytokine signaling 1 (SOCS1) has been shown to play an important role in inhibition of cytokine signal transduction. Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity, and in the methods of restraining SOCS1's function have also made significant progress.