Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (10): 612-614.doi: 10.3760/cma.j.cn371439-20220414-00121

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Research progress of FOXO1 in oral squamous cell carcinoma

Yang Fan1, Guan Xiaoyan1,2, Liu Jianguo2, Xiao Linlin1,2, Yue Chaoyi3, Long Qian1,2, Liao Chengcheng1,2()   

  1. 1Department of Orthodontics Ⅱ, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi 563000, China
    2Guizhou Provincial Key Laboratory of Oral Disease Research in Colleges and Universities, Zunyi 563000, China
    3School of Medicine and Technology, Zunyi Medical University, Zunyi 563000, China
  • Received:2022-04-14 Revised:2022-05-16 Online:2022-10-08 Published:2022-12-01
  • Contact: Liao Chengcheng E-mail:lcc_950330@163.com
  • Supported by:
    National Key Research and Development Program(2016YFC1102800);Guizhou Province Medical Biomaterials Research and Development Talent Base Project(QianRenLingFa [2018] 3)

Abstract:

Forkhead box protein O1(FOXO1) has been extensively studied as a tumor suppressor. In oral squamous cell carcinoma, studies have demonstrated that FOXO1 can inhibit tumor cell oxidative stress, stemness and epithelial-mesenchymal transition, and promote tumor cell autophagy and apoptosis. FOXO1 may serve as a potential target for the treatment of oral squamous cell carcinoma.

Key words: Forkhead box protein O 1, Oral neoplasms