国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (7): 548-550.doi: 10.3760/cma.j.issn.1673-422X.2015.07.020

• 综述 • 上一篇    下一篇

转录因子AP-2在泌尿生殖系统肿瘤中的研究进展

谢宇，范刚，张健   

  1. 410081长沙，湖南师范大学生命科学学院 蛋白质化学与发育生物学教育部重点实验室（谢宇、张健）；中南大学湘雅医学院附属肿瘤医院暨湖南省肿瘤医院泌尿外科（谢宇、范刚）
  • 出版日期:2015-07-08 发布日期:2015-05-26
  • 通讯作者: 张健 E-mail:zhangjian@hunnu.edu.cn
  • 基金资助:

    中南大学中央高校基本科研业务费专项资金（2177/72150050625)

Research progress of transcription factor AP-2 in urogenital cancer

Xie Yu, Fan Gang, Zhang Jian   

  1. Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University; Department of Urology, Hunan Provincial Tumor Hospital, Affiliated Cancer Hospital of Xiangya Medical College, Central South University, Changsha 410081, China
  • Online:2015-07-08 Published:2015-05-26
  • Contact: Zhang Jian E-mail:zhangjian@hunnu.edu.cn

PDF

1358

摘要： 转录因子激活蛋白2（AP2）在肿瘤细胞的增殖、分化、癌变及化疗耐药方面扮演着重要角色。AP2在不同泌尿生殖系统肿瘤组织中分别呈现出抑癌或促癌的双向调控效应。研究AP2在泌尿生殖系统肿瘤中的作用及作用机制可为相关肿瘤的诊治提供新的思路和方向。

关键词: 转录因子AP-2, 泌尿生殖系统肿瘤

Abstract: Transcription factor activator protein2 (AP2) plays an important role in the cancer cell proliferation, differentiation, carcinogenesis and chemotherapy resistance. The effects of AP2 in different urogenital cancers are complex, sometimes acting as cancersuppressor, sometimes as cancerpromoter. Researches on the roles and mechanisms of AP2 in urogenital cancers can provide new ideas and directions for the cancer diagnosis and therapy.

Key words: Transcription factor AP-2, Urogenital neoplasms