国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (12): 902-904.

• 综述 • 上一篇    下一篇

肿瘤干细胞与多药耐药

徐桂芳, 张伟杰, 周志华, 邹晓平   

  1. 210008 南京大学医学院附属鼓楼医院消化科(徐桂芳，邹晓平),科技处(张伟杰) ； 解放军第101医院暨江苏大学临床医院病理科(周志华)
  • 出版日期:2012-12-08 发布日期:2012-11-15
  • 通讯作者: 邹晓平， E-mail:zouxiaoping795 @hotmail.com E-mail:zouxiaoping795 @hotmail.com
  • 基金资助:

    国家自然科学基金资助项目（81000964 81201909）；南京市医学科技发展项目（QYK11166）

Cancer stem cells and multidrug resistance

XU  Gui-Fang, ZHANG  Wei-Jie, ZHOU  Zhi-Hua, ZOU  Xiao-Ping   

  1. Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
  • Online:2012-12-08 Published:2012-11-15
  • Contact: Corresponding author: ZOU Xiao-ping, E-mail:zouxiaoping795 @hotmail.com E-mail:zouxiaoping795 @hotmail.com

PDF

1674

被引次数

5

摘要： 肿瘤的多药耐药(MDR)是导致肿瘤难以根治、化疗失败和疾病复发的主要原因之一。肿瘤干细胞(CSC) 是驱动肿瘤发生、演进、转移和复发的根源，是造成肿瘤耐药的根本原因。CSC主要耐药机制包括：ABC转运体增强CSC的抗药性、高水平表达抗凋亡基因、DNA修复能力增强以及低氧龛环境等。研究CSC生物学特性，阐明其耐药的分子机制，制定出针对CSC的靶向治疗以克服和逆转CSC的多药耐药，有助于提高肿瘤的治愈率和降低复发率。

关键词: 肿瘤干细胞, 化学疗法, 辅助, 药物耐受性

Abstract: Multidrug resistance (MDR) is the main obstacle for cancer to cure, failure of chemotherapy and relapse. Cancer stem cells (CSCs) are driven force for tumorigenesis, the evolution of metastasis and recurrence, and the most fundamental reason for cancer drug-resistance. The primary drug resistance mechanism including: ABC transporters strengthening CSCs drug resistance, high level expression of the anti-apoptotic genes, DNA repair capacity enhancement and hypoxic niches, and so on. To study CSCs biological characteristics and clarify the resistance molecular mechanisms, and to develop a targeted therapy for CSCs, and then to overcome and reverse the multidrug resistance of CSC, will enhance cancer cure rate and reduce the relapse rate.

Key words: Neoplastic stem cells, Chemotherapy, adjuvant, Drug tolerance