国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 163-166.

• 综述 •    下一篇

肿瘤相关成纤维细胞与肿瘤相关性的研究进展

王红梅, 徐军发   

  1. 523808 广东医学院临床免疫学教研室 广东医学院广东省医学分子诊断重点教研室
  • 出版日期:2012-03-08 发布日期:2012-02-24
  • 通讯作者: 徐军发，Email：imxujunfa@163.com E-mail:imxujunfa@163.com
  • 基金资助:

    国家自然科学基金资助项目（30972779）；广东省科技计划项目（2009B030801333）；东莞市科技计划项目（8452402301001083）

Advances of tumor-associated fibroblasts in carcinogenesis

WANG  Hong-Mei, XU  Jun-Fa   

  1. *Department of Clinical Immunology, Guangdong Medical College, Dongguan 523808, China
  • Online:2012-03-08 Published:2012-02-24
  • Contact: Corresponding author: XU Jun-fa, E-mail: imxujunfa@163.com E-mail:imxujunfa@163.com

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摘要： 肿瘤微环境中基质细胞对于肿瘤的发生发展具有重要作用。肿瘤相关成纤维细胞是数量最丰富的基质细胞，在肿瘤微环境中通过细胞与细胞间相互接触，并在各种可溶性因子的作用下，促进上皮细胞及其他细胞恶性转化。

关键词: color: black, font-family: 宋体, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: HE, mso-bidi-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman', mso-ascii-font-family: 'Times New Roman'">血管生成抑制剂, color: black, font-family: 宋体, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: HE, mso-bidi-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman', mso-ascii-font-family: 'Times New Roman'">肿瘤相关成纤维细胞

Abstract: Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor. Tumor-associated fibroblasts (TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors.

Key words: color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Angiogenesis inhibitors, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: HE, mso-fareast-font-family: 宋体">Tumor-associated fibroblast