国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (2): 148-151.

• 综述 • 上一篇    下一篇

血管内皮生长因子与肾细胞癌

周术奎, 王顺平, 王跃闽   

  1. 同济大学附属东方医院泌尿外科
  • 出版日期:2012-02-08 发布日期:2012-01-18
  • 通讯作者: 王跃闽，E-mail: wangyuemin@hotmail.com E-mail:wangyuemin@hotmail.com

Vascular endothelial growth factor and renal cell carcinoma

ZHOU  Shu-Kui, WANG  Shun-Ping, WANG  Yue-Min   

  1. Department of Urology, East Hospital, Tongji University, Shanghai 200120, China
  • Online:2012-02-08 Published:2012-01-18
  • Contact: Corresponding author: Wang Yue-min, E-mail: wangyuemin@hotmail.com E-mail:wangyuemin@hotmail.com

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摘要： 血管内皮生长因子（VEGF）在肾细胞癌组织中高表达，主要受VHL基因和组织缺氧调控，可作为判断肾细胞癌患者肿瘤进展和预后的标志物。近年来将抗VEGF靶向药物用于晚期转移性肾细胞癌治疗，取得良好的临床疗效。

Abstract: Vascular endothelial growth factor（VEGF）is high expression in the organization of renal cell carcinoma and mainly regulate by VHL gene and hypoxic of organization. Moreover, it can be a biomarker to judge renal cell carcinoma tumor progression and prognostic. In recent years, anti-VEGF targeted drugs are used for the treatment of renal cell carcinoma and receive meaningful clinical benefits.