国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (2): 105-107.

• 综述 • 上一篇    下一篇

pim-3基因及其相关作用

孙守亮, 钱军   

  1. 233004 蚌埠，安徽蚌埠医学院第一附属医院肿瘤外三科硕士研究生

  • 出版日期:2012-02-08 发布日期:2012-01-18
  • 通讯作者: 钱军，E-mail：Qianjun215036@sina. E-mail:Qianjun215036@sina.com

Pim-3 gene and its related effect

SUN  Shou-Liang, QIAN  Jun   

  1. Third Department of Surgery Oncology,First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China
  • Online:2012-02-08 Published:2012-01-18
  • Contact: comCorresponding author: QIAN Jun, E-mail: Qianjun215036@sina.com E-mail:Qianjun215036@sina.com

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被引次数

1

摘要： Pim-3作为表达丝氨酸和（或）苏氨酸激酶活性的原癌基因pim家族新成员，与pim-1、pim-2在序列、结构和功能上高度相似，通过磷酸化众多特异性底物而在细胞周期改变、细胞凋亡以及某些肿瘤发生中起重要调控作用。

Abstract: Pim-3, a new member of the the proto-oncogene pim family which expresses serine and threonine kinase activity, shows a high similar to pim-1 and pim-2 at the function, structure and sequence. Pim-3 plays an important regulative role in the cell cycle transform, cell apoptosis and occurrence of the malignant tumors by phosphorylating numerous specific substrates.