国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (12): 920-922.

• 综述 • 上一篇    下一篇

食管癌相关微小RNA研究进展

余江流, 凌志强, 毛伟敏   

  1. 310022 杭州，浙江省肿瘤医院浙江省肿瘤研究所
  • 出版日期:2011-12-08 发布日期:2011-11-25
  • 通讯作者: 凌志强，E-mail:lingzq@hotmail.com E-mail:lingzq@hotmail.com
  • 基金资助:

    浙江省自然科学基金资助项目Y2080749

Progression of microRNA in esophageal cancer

YU  Jiang-Liu, LING  Zhi-Qiang, MAO  Wei-Min   

  1. Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
  • Online:2011-12-08 Published:2011-11-25

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被引次数

3

摘要： 研究发现微小RNA（miRNA）参与细胞的增殖、分化和凋亡等细胞进程，在包括食管癌在内的各种肿瘤中异常表达。miRNA与癌基因或者抑癌基因的mRNA完全或者部分配对，促进mRNA的降解或者抑制mRNA的翻译。研究发现很多miRNA在食管癌的发生发展和预后中发挥重要作用。miR-21与细胞程序性死亡蛋白4（PDCD4）mRNA相结合，抑制PDCD4的翻译从而促进食管癌的发生。miR-106b-25多顺反子经基因扩增激活，其表达产物抑制P21和Bim蛋白的表达，促进了食管癌的发生和发展。

Abstract: Researches find that microRNAs(miRNAs) participate in cell proliferation,differentiation and apoptosis. Dysregulation of miRNA exist in almost all kinds of tumors, including esophageal cancer. MiRNAs bind to mRNA of oncogene or tumor suppressor gene by perfectly or partly base-pair complementarity, and then, promote mRNA degradation or inhibit translation of target mRNA. Recently studies have comfirmed that miRNA function as a significant regulator in esophageal cancer and it is involved in tumorigenesis ,development and prognosis. MiR-21 binds to programmed cell death 4(PDCD4) mRNA and inhibits the translation of PDCD4, then promotes tumorigenesis of esophageal cancer. MiR-106-25 polycistron is activated by genomic amplification, and then suppresses the expressions of P21 and Bim, and subsequently promotes the occurrence and progress of esophageal cancer.