国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (10): 634-637.doi: 10.3760/cma.j.issn.1673-422X.2019.10.015

• 综述 • 上一篇    下一篇

人端粒酶逆转录酶与皮肤恶性肿瘤

赵娟1,康晓静2   

  1. 1新疆医科大学研究生学院,乌鲁木齐8300542新疆维吾尔自治区人民医院皮肤性病科,乌鲁木齐830001

  • 出版日期:2019-10-08 发布日期:2019-12-22
  • 通讯作者: 康晓静, Email: drkangxj666@163.com E-mail:drkangxj666@163.com
  • 基金资助:

    新疆维吾尔自治区自然科学基金(2016D01C101

Human telomerase reverse transcriptase and cutaneous malignant tumor

Zhao Juan1, Kang Xiaojing2   

  1. 1Postgraduate College of Xinjiang Medical University, Urumqi 830054, China; 2Department of Dermatology, Peoples Hospital of Xingjiang Uygur Autonomous Region, Urumqi 830001, China

  • Online:2019-10-08 Published:2019-12-22
  • Contact: Kang Xiaojing, Email: drkangxj666@163.com E-mail:drkangxj666@163.com
  • Supported by:

    Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (2016D01C101)

摘要:

人端粒酶逆转录酶(hTERT)是端粒酶的催化亚单位,与细胞的永生化、肿瘤的发生和细胞的衰老密切相关。hTERT与皮肤恶性肿瘤(黑色素瘤、鳞状细胞癌、基底细胞癌、皮肤淋巴瘤等)的发生、发展有很大的关系,hTERT的异常表达在皮肤恶性肿瘤的早期诊断、个体化综合治疗及预后评估等各个方面均有很重要的临床应用价值。

关键词:

端粒, 皮肤肿瘤, 基因, 人端粒酶逆转录酶

Abstract:

Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase and is closely related to immortalization of cells, tumorigenesis and senescence of cells. hTERT has a great relationship with the occurrence and development of skin malignant tumors (melanoma, squamous cell carcinoma, basal cell carcinoma, cutaneous lymphoma, etc.). Abnormal expression of hTERT has important clinical application value in early diagnosis, individualized comprehensive treatment and prognosis evaluation of cutaneous malignant tumors.

Key words:

Telomere, Skin neoplasms, Genes, Human telomerase reverse transcriptase