国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (3): 187-190.doi: 10.3760/cma.j.issn.1673-422X.2018.03.014

• 综述 • 上一篇    下一篇

中国人群弥漫大B细胞淋巴瘤的特点

张倩,段山   

  1. 518040 深圳市人口和计划生育科学研究所医学遗传学实验室 深圳市出生缺陷干预工程技术研究中心
  • 收稿日期:2017-08-23 出版日期:2018-03-08 发布日期:2018-05-16
  • 通讯作者: 段山 E-mail:szippl@163.com

Characteristics of diffuse large Bcell lymphoma in Chinese populations

Zhang Qian, Duan Shan   

  1. Laboratory of Medical Genetics, Shenzhen Research Institute of Population and Family Planning, Shenzhen Center for Birth Defect Research and Prevention, Shenzhen 518040, China
  • Received:2017-08-23 Online:2018-03-08 Published:2018-05-16
  • Contact: Duan Shan E-mail:szippl@163.com

摘要: 弥漫大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤中最常见的一个类型,通常分为生发中心B细胞样(GCB)和非生发中心B细胞样(nonGCB)两个免疫学亚型,两者在不同人群中的分布和预后均有差异,并且DLBCL在中国人群中有其独特的遗传学特征。随着国内外个体化医疗项目的开展,人们逐渐意识到要根据不同的人群甚至个人来制定具有针对性的治疗方案。

关键词: 淋巴瘤,B细胞, 人种群, 遗传异质性

Abstract: Diffuse large Bcell lymphoma (DLBCL) is the most common type of nonHodgkin lymphoma. Generally, it can be divided into two immunological subgroups: germinal center Bcelllike (GCB) and nongerminal center Bcelllike (nonGCB), and they are different both in distribution and prognosis in different populations. And DLBCL has unique genetic characteristics in Chinese populations. With the global advances in personalized medicine, people gradually realize that only personalized therapy could be obtain maximal therapeutic effect for different populations, especially person from different kind of ethnic group.

Key words: Lymphoma,Bcell, Ethnic groups, Genetic heterogeneity