Journal of International Oncology ›› 2018, Vol. 45 ›› Issue (8): 487-489.doi: 10.3760/cma.j.issn.1673422X.2018.08.008

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Immunological regulation of CD70/CD27 pathway and the expression of CD70 in tumor

Liu Zhenzhen, Kong Yingjun, Sun Wenxue, Li Shimin, Zhang Min, Yin Hesong   

  1. Department of Respiratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Online:2018-08-08 Published:2018-11-01
  • Contact: Kong Yingjun E-mail:kyjtoday@sina.com

Abstract: CD70/CD27 pathway plays an important role in human immune regulation. The role of CD70/CD27 pathway in immune regulation is mainly to promote the activation and proliferation of T cells, induce the differentiation and formation of effector T cells and memory T cells, and interfere with regulatory T cells. In addition, the high level of CD70 expression in some tumor cells provides a new way for tumor immunotherapy.

Key words: Immunity, cellular, Neoplasms, CD70/CD27 pathway