Journal of International Oncology ›› 2018, Vol. 45 ›› Issue (2): 119-121.doi: 10.3760/cma.j.issn.1673422X.2018.02.014

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Pathogenesis of ethanolinduced esophageal cancer

Lin Tao, Ma Dongchun, Wang Hua, Xie Mingran, Zhang Tianci   

  1. Department of Toracic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China
  • Online:2018-02-08 Published:2018-02-28
  • Contact: Ma Dongchun E-mail:madongchun126@126.com
  • Supported by:

    Scientific Research Project of Health and Family Planning Commission of Anhui Province of China(15tb006)

Abstract: Ethanol is one of the major risk factors for esophageal cancer. The main mechanisms of ethanol induced esophageal cancer include the direct carcinogenesis of acetaldehyde, the genetic polymorphism of enzymes related to alcohol metabolism, the carcinogenic effect of reactive oxygen species, the disorder of nutrient metabolism induced by ethanol, and the synergistic effect of ethanol and tobacco.  

Key words: Esophageal neoplasms, Ethanol