Journal of International Oncology ›› 2018, Vol. 45 ›› Issue (2): 103-106.doi: 10.3760/cma.j.issn.1673422X.2018.02.010

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Roles of platelets in tumor progression

Chen Luojun, Tian Jingyuan, Li Na, Song Qibin   

  1. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Online:2018-02-08 Published:2018-02-28
  • Contact: Song Qibin E-mail:qibinsong@163.com
  • Supported by:

    National Natural Science Foundation of China (81372407); Natural Science Foundation of Hubei Province of China (2015CFB409)

Abstract: Platelets play  important roles in tumor progression. Increased platelets count is associated with poor overall survival and prognosis. Tumor cellinduced platelet activation and plateletinduced tumor growth form a malignant amplification loop which plays a crucial role in tumor cell proliferation, metastasis and angiogenesis. Antiplatelet therapy may break the platelettumor amplification loop and play a key role in reducing tumor metastasis.

Key words: Blood platelets, Neoplasms