Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity

doi:10.3760/cma.j.issn.1673422X.2018.02.009

Abstract

Abstract: Generally speaking, the organism can maintain the stability of T cells. The lymphopeniainduced homeostatic proliferation of T cells could be driven by the recognition of autoantigen including tumor antigen in the absence of foreign antigens or inflammatory signals. This process can break tumorinduced immune tolerance and induce a powerful antitumor immunity. It is confirmed that some negative immune molecules are recruited during the homeostatic proliferation, then the antitumor immunity will be impaired.

Key words: Cell proliferation, Lymphopenia, Immune tolerance

LAI Nan, CHEN Ze-Hong, YANG Zi-Ke, LIU Yan-You-Hong, KANG Shi-Jun. Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity[J]. Journal of International Oncology, 2018, 45(2): 100-102.

References

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