Abstract: APOBEC3B is one member of APOBEC with the activity of cytosine deaminase. Researches show that APOBEC3B can take park in the development and progression of breast cancer by means of mediating the genome mutations, which can promote cancer metastasis and drug resistance, thus influencing the treatment effect of patients with cancers. APOBEC3B is closely related with clinical prognosis of breast cancer, which has a potential value in the early diagnosis and biological therapy of breast cancer and provides a new hope for the treatment of breast cancer.

Key words: Breast neoplasms, Mutation, Prognosis, Apolioprotein B mRNAediting enzyme catalytic polypeptide 3B