Abstract: Collective migration is the essential movement style in embryonic development. Recent studies have found that collective migration is one of the main movement styles in invasion and metastasis of tumor cells. Tumor cells can invade into the stroma and microvascular in group, and the collective migration shows the unique characters when compared to the single cell movement. The potential mechanisms are closely correlated to the cellcell connection and interaction between tumor cells and microenvironment. With the gradual improvement of the observation models, the mechanisms about the physical or chemical guidance, the related signaling pathways, and the epigenetic regulation in collective migration will be elucidated.

Key words: Neoplasms, Cell movement, Cell migration, Models