Abstract: The chemosensitivity enhancive mechanism on nitric oxide includes three routes: adjust the expression level of hypoxiainducible factor1α (HIF1α）, classical nitric oxide signal pathway and combine with the reaction products of other molecules. Traditional nitric oxide donor compounds include nitroferricyanide, organic nitrates, snitrosothiols, azo onium diol aldoxide, nonsteroids antiinflammatory drugs, whose function of antitumor and chemotherapy sensitization caused extensive attention.

Key words: Nitric oxide donors, Neoplasms, Chemosensitizer