Signaling pathways of epithelialmesenchymal transition in colon cancer

doi:10.3760/cma.j.issn.1673422X.2016.05.017

Abstract

Abstract: Epithelialmesenchymal transition (EMT) plays a critical role in the carcinogenesis of colon cancer, and promotes the tumor invasion and metastasis. Studies have shown several signals are involved including transforming growth factorβ (TGFβ), Wnt/βcatein, Notch, nuclear factorκB (NFκB) and PI3K/Akt signal pathway. It is important to elucidate EMTrelated signal pathway thereby providing new insights into possible therapeutic interventions of colon cancer.

Key words: Colorectal neoplasms, Epithelialmesenchymal transition

Li Xiaoqing, Li Yuanfei. Signaling pathways of epithelialmesenchymal transition in colon cancer[J]. Journal of International Oncology, 2016, 43(5): 385-386.

References

［1］ Fuxe J, Karlsson MC. TGFβinduced epithelialmesenchymal transition: a link between cancer and inflammation［J］. Semin Cancer Biol, 2012, 22(5/6): 455-461. DOI: 10.1016/j.semcancer.2012.05.004. ［2］ Hirakawa M, Takimoto R, Tamura F, et al. Fucosylated TGFbeta receptors transduces a signal for epithelialmesenchymal transition in colorectal cancer cells［J］. Br J Cancer, 2014, 110(1): 156-163. DOI: 10.1038/bjc.2013.699. ［3］ Arend RC, LondooJoshi AI, Straughn JM, et al. The Wnt/βcatenin pathway in ovarian cancer: a review［J］. Gynecol Oncol, 2013, 131(3): 772-779. DOI: 10.1016/j.ygyno.2013.09.034. ［4］ Cao H, Xu E, Liu H, et al. Epithelialmesenchymal transition in colorectal cancer metastasis: a system review［J］. Pathol Res Pract, 2015, 211(8): 557-569. DOI: 10.1016/j.prp.2015.05.010. ［5］ Wang Z, Li Y, Kong D, et al. The role of Notch signaling pathway in epithelialmesenchymal transition (EMT) during development and tumor aggressiveness［J］. Curr Drug Targets, 2010, 11(6): 745-751. ［6］ Kopan R. Notch signaling［J］. Cold Spring Harb Perspect Biol, 2012, 4(10): 23028119. DOI: 10.1101/cshperspect.a011213. ［7］ Chu D, Zhang Z, Zhou Y, et al. Notchl and notch2 have opposite prognostic effects on patients with colorectal cancer［J］. Ann Oncol, 2011, 22(11): 2440-2447. DOI: 10.1093/annonc/mdq776. ［8］ Li CW, Xia W, Huo L, et al. Epithelialmesenchymal transition induced by TNFα requires NFκBmediated transcriptional upregulation of Twist1［J］. Cancer Res, 2012, 72(5): 1290-1300. DOI: 10.1158/00085472.CAN113123. ［9］马冬华, 张亮, 王亚旭. 磷脂酰肌醇3激酶蛋白激酶B信号通路在结肠癌中的作用［J］. 国际肿瘤学杂志, 2012, 39(2): 143-145. DOI: 10.3760/cma.j.issn.1673422X.2012.02.020. ［10］ Wang G, Yang X, Li C, et al. PIK3R3 induces epithelialtomesenchymal transition and promotes metastasis in colorectal cancer［J］. Mol Cancer Ther, 2014, 13(7): 1837-1847. DOI: 10.1158/15357163.MCT140049. ［11］ Chen XF, Zhang HJ, Wang HB, et al. Transforming growth factorβ1 induces epithelialtomesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways［J］. Mol Biol Rep, 2012, 39(4): 3549-3556. DOI: 10.1007/s1103301111280.

[1]	Zhang Rui, Chu Yanliu. Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota [J]. Journal of International Oncology, 2024, 51(6): 370-375.
[2]	Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer [J]. Journal of International Oncology, 2024, 51(6): 376-381.
[3]	Wang Junyi, Hong Kaibin, Ji Rongjia, Chen Dachao. Effect of cancer nodules on liver metastases after radical resection of colorectal cancer [J]. Journal of International Oncology, 2024, 51(5): 280-285.
[4]	Sun Guobao, Yang Qian, Zhuang Qingchun, Gao Binbin, Sun Xiaogang, Song Wei, Sha Dan. Research progress on the histopathological growth patterns of colorectal liver metastasis [J]. Journal of International Oncology, 2024, 51(2): 114-118.
[5]	Liu Debao, Sun Ziwen, Lu Shoutang, Xu Haidong. Expression and clinical significance of ASB6 in colorectal cancer tissues [J]. Journal of International Oncology, 2023, 50(8): 470-474.
[6]	Chen Zhuo, Tao Jun, Chen Lin, Ke Jing. Value of detection of peripheral blood miR-194 combined with fecal miR-143 in the clinical screening of colorectal cancer [J]. Journal of International Oncology, 2023, 50(5): 268-273.
[7]	Huang Zhen, Zhang Caiyutian, Ke Shaobo, Shi Wei, Zhao Wensi, Chen Yongshun. Construction of postoperative prognosis model for patients with colorectal cancer [J]. Journal of International Oncology, 2023, 50(3): 157-163.
[8]	Xu Liangfu, Li Yuanfei. Research progress on tumor microenvironment and immune combination therapy of MSS colorectal cancer [J]. Journal of International Oncology, 2023, 50(3): 186-190.
[9]	Liu Yujie, Zhao Zhiqiang, Wang Zicheng. Levels and diagnostic value of TOP2A and ERBB2 in peripheral blood mononuclear cells of patients with early colorectal cancer [J]. Journal of International Oncology, 2023, 50(12): 717-722.
[10]	Tao Hong, Yin Hong, Luo Hong, Tao Jiayu. Potential strategies for targeting tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors for colorectal cancer [J]. Journal of International Oncology, 2023, 50(11): 683-687.
[11]	Wang Xi, Wu Chuanqing. Research progress in reversing multidrug resistance in colorectal cancer [J]. Journal of International Oncology, 2023, 50(1): 42-46.
[12]	Gao Yizhao, Liu Yang, Liu Qiulong, Xing Jinliang. Application of circulating cell-free nucleic acid in clinical diagnosis and treatment of colorectal cancer [J]. Journal of International Oncology, 2022, 49(9): 555-559.
[13]	He Zhefeng, Wu Yiyang, Li Zhenjun, Ying Xiaojiang. Predictive value of inflammatory markers in colorectal cancer [J]. Journal of International Oncology, 2022, 49(9): 560-563.
[14]	Zhao Ying, Zhang Gehong. Study on the correlations between AGR, PLR and NLR changes and chemotherapy efficacy of metastatic colorectal cancer [J]. Journal of International Oncology, 2022, 49(8): 473-477.
[15]	Huang Mengpan, Wang Xuehong, Lu Yongfu. Mechanism of FOXA2 in colorectal cancer and its application in diagnosis and treatment [J]. Journal of International Oncology, 2022, 49(8): 490-493.